Developing flow photo-thiol–ene functionalizations of cinchona alkaloids with an autonomous self-optimizing flow reactor
نویسندگان
چکیده
Continuous flow photo-thiol–ene reactions on cinchona alkaloids with a variety of organic thiols have been developed using enabling technologies such as self-optimizing photochemical reactor.
منابع مشابه
An Overview of Cinchona Alkaloids in Chemistry
Cinchona alkaloids (Figure 1.1), isolated from the bark of several species of cinchona trees, are the organic molecules with the most colorful biography [1]. Their history dates back to the early seventeenth century when they were first introduced into the European market after the discovery of the antimalarial property of cinchona bark and the subsequent isolation of its active compound, quini...
متن کاملThe Alkaloids of Cinchona
?n observations on the action o alkaloids in causing disappearance o parasites during an acute attack. Reports were received: , 7 (1) From Colonel Harvey who tinted 7 cases of benign tertian malaria with q bisulphate, 10 grains for 70 kilogrammes 'body weight. The drug was dissolved m dilute sul Phuric acid, one dose was given before break fast and one before the evening mea . Eleven patients w...
متن کاملThe Amorphous Cinchona Alkaloids
Quinoidine was greater than that of Quinine and this honour has often been awarded to it since, though very little of the drug appears to have been used except as a tonic for horses. Major Waters' recent paper in the IMG seems to be having a greater effect on its sale. In every Quinine factory Quinine alone has been the important product. The other alkaloids are listed and occasionally one or o...
متن کاملChiral imprinting of palladium with cinchona alkaloids.
In the search for new materials and concepts in materials science, metallo-organic hybrids are attractive candidates; they can combine the rich diversity of organic molecules with the advantages of metals. Transition metals such as palladium are widely applied in catalysis, and small organic molecules such as those in the cinchona alkaloid family can control the stereochemistry of a number of o...
متن کاملTreatment of angina pectoris with cinchona alkaloids.
Reports indicating the value of quinidine sulfate in angina pectoris led to (1) a search for related drugs which were equally effective but less toxic, and (2) a study of the mode of action of these drugs. It was found that quinidine, quinine, cinchonadine, and cinchamidine decrease the frequency of attacks in daily life and increase the exercise tolerance as measured by a standardized test. Qu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Reaction Chemistry and Engineering
سال: 2022
ISSN: ['2058-9883']
DOI: https://doi.org/10.1039/d1re00509j